A putative int domain for mouse mammary tumor virus on mouse chromosome 7 is a 5' extension of int-2. |
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| Authors: | G Peters S Brookes M Placzek M Schuermann R Michalides and C Dickson |
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| Institution: | Imperial Cancer Research Fund Laboratories, St. Bartholomews Hospital, London, United Kingdom. |
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| Abstract: | We extended the physical map of the mouse int-2 locus by demonstrating that the site of insertion for mouse mammary tumor virus DNA in plaque-type mammary tumors of GR mice is directly linked to int-2. An additional example of proviral integration is described in which a provirus in a presumed enhancer-insertion mode 15 kilobases upstream of the int-2 promoters is capable of activating expression of the gene at levels typical of other virally induced mammary tumors. |
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