MaXLinker: Proteome-wide Cross-link Identifications with High Specificity and Sensitivity期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

MaXLinker: Proteome-wide Cross-link Identifications with High Specificity and Sensitivity

Affiliation:	3. Department of Computational Biology, Cornell University, Ithaca, New York,14853;4. Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York, 14853;5. Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853;6. Mass Spectrometry and Proteomics Facility, Institute of Biotechnology, Cornell University, Ithaca, New York,14853

Abstract:	Download : Download high-res image (339KB) Download : Download full-size image Highlights •New quality assessment metrics to evaluate proteome-wide cross-linking mass spectrometry (XL-MS) data sets. •New “MS3-centric” cross-link search engine named MaXLinker with high sensitivity and specificity. •More than 9300 cross-links from our human proteome-wide XL-MS study. •Orthogonal experimental validation of novel interactions identified in our study.

Keywords:	Protein cross-linking systems biology protein-protein interactions computational biology mass spectrometry
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