Upregulation of CD73 Confers Acquired Radioresistance and is Required for Maintaining Irradiation-selected Pancreatic Cancer Cells in a Mesenchymal State
Institution:
Department of Biological Sciences, University of Arkansas, Fayetteville, Arkansas
Abstract:
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Highlights
•CD73 is one of the most upregulated proteins in the radioresistant cells.
•CD73 upregulation confers radioresistance and irradiation-induced apoptosis.
•CD73 confers radioresistance potentially through inactivating protein BAD.
•Elevated CD73 is required for maintaining the resistant cells in a mesenchymal state.
