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Integration of IgA and IgG Autoantigens Improves Performance of Biomarker Panels for Early Diagnosis of Lung Cancer
Affiliation:3. Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205;4. Provincial Clinical College, Fujian Medical University, Fuzhou 350001, Fujian, China;5. Department of Clinical Laboratory, Fujian Provincial Hospital, Fuzhou 350001, Fujian, China;6. Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205;12. The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21205;8. Center for Experimental Research in Clinical Medicine, Fujian Provincial Hospital, Fuzhou 350001, Fujian, China
Abstract:
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  • Highlights
    • •HuProt array-based identification of autoantigens in serum of early lung cancer.
    • •Independent validation of early lung cancer biomarker candidates with ELISA.
    • •Bioinformatics-aided identification of a biomarker panel.
    • •Independent verification of the panel with ELISA and immunohistochemistry.
    Keywords:Lung cancer  cancer biomarker(s)  early diagnosis  protein array  high throughput screening  caner early diagnosis  ELISA  HuProt array  lung cancer  serological biomarkers
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