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STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth
Affiliation:1. Department of Immuno-Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA;2. Sorrento Therapeutics Inc. 4955 Directors PI, San Diego, CA 92121, USA;3. Department of Immunology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA;4. Department of Hematology and Hematopoietic Cell Transplantation, City of Hope Medical Cancer Center, Duarte, CA 91010, USA;5. Department of Medical Oncology & Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA;6. Department of Pathology, City of Hope Medical Center, Duarte, CA 91010, USA;7. Department of Surgery, City of Hope Medical Center, Duarte, CA 91010, USA;8. Department of Translational Molecular Medicine, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA;9. Diabetes & Metabolism Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA
Abstract:
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  • Keywords:obesity  FAO  PD-1  leptin  CD8 T cells  tumor  STAT3  IFNγ
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