The Risk of Thyroid Cancer in Patients with Thyroid Nodule 3 Cm Or Larger |
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| Affiliation: | 1. From the Chung Shan Medical University Hospital, Department of Internal Medicine, Division of Endocrinology and Metabolism, Institute of Medicine, Taichung, Taiwan;2. The Chung Shan Medical University, School of Medicine, Institute of Medicine, Taichung, Taiwan;3. Chung Shan Medical University, Institute of Medicine, Taichung, Taiwan.;1. Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China;2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China;3. Department of Head and Neck Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.;1. From the Thyroid Center, Shanghai Tenth People''s Hospital, Tongji University School of Medicine, Shanghai Center for Thyroid Diseases, Shanghai, People''s Republic of China;2. Department of Nuclear Medicine, Shanghai Tenth People''s Hospital, Tongji University School of Medicine, Shanghai, People''s Republic of China;3. Department of Medical Management, Shanghai Tenth People''s Hospital, Tongji University School of Medicine, Shanghai, People''s Republic of China;4. Department of Breast Surgery, XuZhou Central Hospital, The Affiliated XuZhou Hospital of Medical College of Southeast University, Xuzhou, People''s Republic of China.;1. Department of Medicine, University of Chicago, Chicago, IL, USA;2. Department of Pathology, University of Chicago, Chicago, IL, USA;3. Department of Health Studies, University of Chicago, Chicago, IL, USA;4. Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;5. Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;6. Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;7. Department of Biomedical and Clinical Sciences “Luigi Sacco”, Università degli Studi, Milan, Italy |
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| Abstract: | Objective: There are conflicting data on the risk of thyroid cancer in thyroid nodules 3 cm or larger, and few such studies on this issue have been conducted in Asia. This study aimed to examine the risk of thyroid cancer in patients with thyroid nodules 3 cm or larger.Methods: This was a 7-year retrospective study conducted in a tertiary referral hospital in Taiwan. All patients with a thyroid nodule measuring ≥3 cm who underwent thyroid operation with or without fine-needle aspiration biopsy (FNAB) were included. The prevalence rate of thyroid cancer, as well as the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and false-negative rate of FNAB for thyroid nodule ≥3 cm were also examined.Results: A total of 132 patients were included in this study. Thyroid cancer was detected in 19 of 132 (14.4%) thyroid nodules measuring ≥3 cm. The performance of FNAB for detecting cancer in nodules 3 cm or larger without considering other ultrasonography parameters was relatively poor with a sensitivity of 50%, but the specificity (100%), PPV (100 %), and NPV (93.4 %) were excellent.Conclusion: The risk of thyroid cancer for thyroid nodules ≥3 cm in this study was low. The PPV and NPV of FNAB were high for the detection of cancer in large nodules. The decision to perform thyroidectomy should not be solely based on nodule size and should include other factors, such as ultrasound characteristics and surgical risk. |
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