The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins
Institution:
3. Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool L3 5RF, UK;4. Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queens University Belfast, Belfast BT9 7BL, UK;5. NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, L69 7BE, UK;6. Biomedical Research Administration, Research Centre, King Fahad Medical City, P.O. Box 59046 Riyadh 11252, Saudi Arabia;12. Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore 138648, Singapore
Abstract:
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Highlights
•Proteome of airway secretions derived from mock- and hRSV-infected WD-PBEC cultures.
•A polarised secretome in uninfected WD-PBECs, skewed in hRSV-infected cultures.
•CXCL6, CXCL16, CECACAM1 and CSF3 induced only upon hRSV-infection.
•Detection of CXCL6, CXCL16 and CSF3 in NPAs from hRSV-positive children.
