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Changes in the Oligodendrocyte Progenitor Cell Proteome with Ageing
Authors:Alerie G de la Fuente  Rayner ML Queiroz  Tanay Ghosh  Christopher E McMurran  Juan F Cubillos  Dwight E Bergles  Denise C Fitzgerald  Clare A Jones  Kathryn S Lilley  Colin P Glover  Robin JM Franklin
Institution:1. Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, United Kingdom;2. Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, United Kingdom;3. Respiratory, Inflammation and Autoimmunity, MedImmune Ltd., Granta Park, United Kingdom;4. Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke''s Hospital, Hills Road, Cambridge, United Kingdom;5. The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, USA;6. John Hopkins University, Kavli Neuroscience Discovery Institute, USA;7. Wellcome-Wolfson Institute for Experimental Medicine, Queen''s University Belfast, United Kingdom;8. Oncology Early Clinical Projects, Oncology R &D, AstraZeneca, Melbourn Science Park, Melbourn, Hertfordshire, United Kingdom
Abstract:
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  • Highlights
    • ?Quantitative proteome of neonatal, young, and aged OPCs.
    • ?50% of the proteome is differentially expressed between neonatal and adult OPCs.
    • ?Myelin proteins are increased, and cholesterol synthesis proteins decreased with age.
    • ?Proteins associated with other neurodegenerative diseases are increased in aged OPCs.
    Keywords:Aging  stem cells  neurodegenerative diseases  neurobiology  progenitor cells  multiple sclerosis  myelin  oligodendrocyte  regeneration
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