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Investigation of Inter- and Intratumoral Heterogeneity of Glioblastoma Using TOF-SIMS
Affiliation:3. N.N. Semenov Federal Research Center for Chemical Physics, Moscow, Russia;4. Department of Chemistry, Lomonosov Moscow State University, Moscow Russia;5. Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia;6. Moscow Institute of Physics and Technology, Moscow Region, Russia;12. Department of Neurosurgery, University of Alabama at Birmingham, Wallace Tumor Institute, Birmingham, Alabama;8. Federal State Autonomous Institution, N.N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia
Abstract:
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  • Highlights
    • •TOF-SIMS allows to visualize normal brain and tumor border.
    • •Glioma samples can be subdivided into clinically relevant groups by TOF-SIMS data.
    • •TOF-SIMS allows to simultaneously detect proteins and metabolites in clinical samples.
    Keywords:Glioblastoma  stem cells  mass spectrometry  cancer biomarker(s)  imaging visualization tools  caveolin-1  glioma  TOF-SIMS
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