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Molecular Basis of the Mechanisms Controlling MASTL
Institution:3. The Novo Nordisk Foundation Center for Protein Research, Protein Structure & Function Programme, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark;4. The Novo Nordisk Foundation Center for Protein Research, Proteomics Programme, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark;5. Protein Analysis Group, Department of Pharmacy, Faculty of Health and Medical Sciences, University of CopenhagenCopenhagen, Denmark;6. Cell Division and Cancer Group, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain
Abstract:
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  • Highlights
    • ?NCMR is crucial for substrate recognition and activity regulation.
    • ?MASTL conserves a cryptic C-Lobe in the non-conserved middle region.
    • ?MASTL450 containing the cryptic C-lobe is observed in cancer cell lines.
    • ?Key phosphorylation sites for MASTL provide an activation model.
    Keywords:Kinases  mitosis  protein phosphatases  cell cycle  cancer biology
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