Kinome Profiling of Primary Endometrial Tumors Using Multiplexed Inhibitor Beads and Mass Spectrometry Identifies SRPK1 as Candidate Therapeutic Target期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Kinome Profiling of Primary Endometrial Tumors Using Multiplexed Inhibitor Beads and Mass Spectrometry Identifies SRPK1 as Candidate Therapeutic Target

Authors:	Alison M. Kurimchak,Vikas Kumar,Carlos Herrera-Montá vez,Katherine J. Johnson,Nishi Srivastava,Karthik Davarajan,Suraj Peri,Kathy Q. Cai,Gina M. Mantia-Smaldone,James S. Duncan

Affiliation:	1. Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA;2. Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA;3. Histopathology Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA;4. Division of Gynecologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

Abstract:	Download : Download high-res image (218KB) Download : Download full-size image Highlights •SRPK1 is overexpressed in endometrial cancer and associated with poor survival. •SRPK1 promotes endometrial cancer cell growth under nutrient-deprived conditions. •Activation of EGFR-IGF1R-AKT signaling promotes resistance to SRPK1 inhibitors. •Co-targeting SRPK1 and EGFR-IGF1R synergize blocking endometrial cancer cell growth.

Keywords:	kinases cancer biomarker(s) pathway analysis affinity proteomics therapeutic targets combination therapies endometrial carcinoma kinome splicing tissue proteomics
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