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Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids
Affiliation:1. Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA;2. Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA;3. Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA;4. Division of Hematology & Medical Oncology, Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, USA;5. Sahlgrenska Cancer Center, Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, 405 30 Gothenburg, Sweden;6. Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden
Abstract:
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  • Keywords:NRF2  Keap1  lung cancer  non-essential amino acids  glutamate  asparaginase  metabolism  oxidative stress  amino acid synthesis  glutaminase
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