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AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair
Affiliation:3. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030;4. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030
Abstract:
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  • Highlights
    • •Each component of the AMPK trimeric complex was profiled by interaction proteomics.
    • •The subunit composition of the AMPK complex directs interactions to distinct proteins.
    • •AMPK interacts with Artemis and plays a role in Non-Homologous End Joining.
    Keywords:Kinases  knockouts  mass spectrometry  non-covalent interaction MS  protein complex analysis  protein identification  protein-protein interactions
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