The DNA Sensor cGAS is Decorated by Acetylation and Phosphorylation Modifications in the Context of Immune Signaling期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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The DNA Sensor cGAS is Decorated by Acetylation and Phosphorylation Modifications in the Context of Immune Signaling

Institution:	Department of Molecular Biology, Princeton University, Princeton, New Jersey

Abstract:	Download : Download high-res image (285KB) Download : Download full-size image Highlights ?cGAS acetylations and phosphorylations under basal and immune-stimulated states. ?K384 and K414 acetylations and S305 phosphorylation inhibit cGAS-mediated apoptosis. ?Acetylation at K198 stimulates cGAS-dependent interferon signaling. ?K198 acetylation is decreased upon herpesvirus infection.

Keywords:	Affinity proteomics post-translational modifications phosphorylation acetylation parallel reaction monitoring immunology viruses immunoaffinity purification innate immunity
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