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Mass Spectrometry Based Immunopeptidomics Leads to Robust Predictions of Phosphorylated HLA Class I Ligands
Institution:3. Department of Oncology, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland;4. Swiss Institute of Bioinformatics, Lausanne, Switzerland;5. Department of Oncology, Ludwig Institute for Cancer Research, University Hospital of Lausanne, Lausanne, Switzerland
Abstract:
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  • Highlights
    • ?Curation of 2066 phosphorylated HLA class I peptides from immunopeptidomics data.
    • ?Determination of 22 HLA class I binding motifs for phosphorylated peptides.
    • ?Observation of a higher frequency of phosphorylated ligands binding HLA-C molecules.
    • ?Development of a predictor of phosphorylated peptide interactions with HLA class I.
    Keywords:Mass spectrometry  immunology  phosphorylation  peptidomics  computational biology  computational immunology  HLA peptidomics  HLA-I ligand predictions  phosphorylated HLA-I binding motifs  phosphorylated HLA-I ligands
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