Thorough Performance Evaluation of 213 nm Ultraviolet Photodissociation for Top-down Proteomics期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Thorough Performance Evaluation of 213 nm Ultraviolet Photodissociation for Top-down Proteomics

Institution:	3. Departments of Chemistry and Molecular Biosciences, and the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois 60208;4. Thermo Fisher Scientific, San Jose, California 95134;5. Proteinaceous Inc., Evanston, Illinois 60201

Abstract:	Download : Download high-res image (199KB) Download : Download full-size image Highlights •Analysis of product ions produced by 213 nm UVPD is used to refine database search. •A product ion at the N-terminus of Pro, y-2, is observed in 213 nm UVPD spectra. •213 nm UVPD provides more complete proteoform characterization than HCD. •HCD and 213 nm UVPD are complementary fragmentation methods for proteoforms <30 kDa.

Keywords:	Fourier transform MS mass spectrometry post-translational modifications protein identification tandem mass spectrometry FDR product ion proteoform top-down proteomics UVPD
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