Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound,JPC-3210, Against Plasmodium falciparum
Institution:
3. Australian Defense Force Malaria and Infectious Disease Institute, Brisbane, Australia;4. Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia;5. Jacobus Pharmaceutical Company, Plainsboro, New Jersey
Abstract:
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Highlights
•Multi-omics analysis on mode of action of novel antimalarial, JPC-3210
•JPC-3210 has rapid parasite killing kinetics.
•Metabolomics and peptidomics demonstrated JPC-3210 inhibits hemoglobin digestion.
•Proteomics demonstrated JPC-3210 enriches for translation regulation proteins.
