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Phenotypic Adaption of Pseudomonas aeruginosa by Hacking Siderophores Produced by Other Microorganisms

Institution:	3. Université de Strasbourg, UMR7242, ESBS, Bld Sébastien Brant, F-67413 Illkirch, Strasbourg, France;4. CNRS, UMR7242, ESBS, Bld Sébastien Brant, F-67413 Illkirch, Strasbourg, France;5. Laboratoire de Spectrométrie de Masse BioOrganique, Université de Strasbourg, CNRS, IPHC UMR 7178, F-67000 Strasbourg, France;6. Plateforme Proteomique Strasbourg - Esplanade, Institut de Biologie Moléculaire et Cellulaire, CNRS, FR1589, 15 rue Descartes, F-67084 Strasbourg Cedex, France

Abstract:	Download : Download high-res image (158KB) Download : Download full-size image Highlights •P. aeruginosa grown with exosiderophores and analyzed by proteomic and RT-qPCR. •Catechol-type exosiderophores strongly induce the expression of their transporters. •Repression of the endogenous iron uptake pathways. •Complex phenotypic plasticity in the expression of the various iron-uptake pathways.

Keywords:	Label-free quantification mass spectrometry microbiology molecular biology pathogens iron homeostasis phenotypic plasticity Pseudomonas siderophore TonB transporters
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