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Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming
Affiliation:1. Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada;2. Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada;3. Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montréal, QC H2X 0A9, Canada;4. Department of Neuroscience, Faculty of Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada;5. Metabolic and Nutritional Programming, Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA;6. The Lady Davis Institute of the Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada;7. Department of Oncology, McGill University, Montreal, QC, Canada;8. Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA;9. Center for Human Immunology and Immunotherapy Programs, Washington University at St. Louis, St. Louis, MO 63110, USA;10. Agios Pharmaceuticals, Cambridge, MA 02139, USA;11. Metabolic and Nutritional Programming, Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA;12. Institut du Cancer de Montréal, Montreal, QC H2X 0A9, Canada;13. Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université de Montréal, Montreal, QC H3T 1J4, Canada;14. Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada
Abstract:
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  • Keywords:T cells  metabolism  methionine  SAM  histone methylation  Th17 cells  EAE  inflammation
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