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Profiling the Surfaceome Identifies Therapeutic Targets for Cells with Hyperactive mTORC1 Signaling

Institution:	3. Department of Radiology and Biomedical Imaging, University of California San Francisco 505 Parnassus Ave, San Francisco California 94143;4. Department of Pharmaceutical Chemistry, University of California San Francisco, 505 Parnassus Ave, San Francisco California 94143;5. Imagerie Moleculaire In Vivo, INSERM, CEA, Univ. Paris Sud, CNRS, Universite Paris Saclay, CEA-Service Hospitalier Frederic Joliot, Orsay France, 94100;6. Department of Urology, University of California San Francisco, 505 Parnassus Ave, San Francisco California 94143

Abstract:	Download : Download high-res image (227KB) Download : Download full-size image Highlights •Quantitative proteomes of the cellular surface changes induced by mTORC1 signaling. •Hit validation in human cancer cell lines and biopsies. •Functional studies showing new drug targets to which cancer cells with hyperactive mTORC1 may be addicted. •A new paradigm for drug development, namely targeting cell surface proteins regulated by mTORC1.

Keywords:	SILAC drug targets membranes mouse models cell biology cancer therapeutics cancer biology
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