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Chemical Genetics of AGC-kinases Reveals Shared Targets of Ypk1, Protein Kinase A and Sch9
Institution:3. Department of Molecular Biology, University of Geneva, CH-1211, Geneva, Switzerland;4. National Centre of Competence in Research - Chemical Biology, University of Geneva, CH-1211, Geneva, Switzerland;5. Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland;6. Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, CH-8093 Zürich, Switzerland;12. Faculty of Science, University of Zurich, CH-8006, Zurich, Switzerland
Abstract:
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  • Highlights
    • •Acute inhibition of growth-regulatory AGC-kinases Sch9, PKA and Ypk1.
    • •Phospho-proteomic profiling of 6373 phsopho-sites.
    • •Ypk1 regulates phospho-sites in RRxS/T-context and functionally overlaps with PKA.
    • •Ypk1 and PKA activate trehalase activity of Nth1.
    Keywords:Enzyme inhibition  label-free quantification  phosphoproteome  protein kinases  protein motifs  yeast  AGC-kinases  cell growth  chemical genetics  trehalase
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