Chemical Genetics of AGC-kinases Reveals Shared Targets of Ypk1, Protein Kinase A and Sch9期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Chemical Genetics of AGC-kinases Reveals Shared Targets of Ypk1, Protein Kinase A and Sch9

Institution:	3. Department of Molecular Biology, University of Geneva, CH-1211, Geneva, Switzerland;4. National Centre of Competence in Research - Chemical Biology, University of Geneva, CH-1211, Geneva, Switzerland;5. Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland;6. Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, CH-8093 Zürich, Switzerland;12. Faculty of Science, University of Zurich, CH-8006, Zurich, Switzerland

Abstract:	Download : Download high-res image (245KB) Download : Download full-size image Highlights •Acute inhibition of growth-regulatory AGC-kinases Sch9, PKA and Ypk1. •Phospho-proteomic profiling of 6373 phsopho-sites. •Ypk1 regulates phospho-sites in RRxS/T-context and functionally overlaps with PKA. •Ypk1 and PKA activate trehalase activity of Nth1.

Keywords:	Enzyme inhibition label-free quantification phosphoproteome protein kinases protein motifs yeast AGC-kinases cell growth chemical genetics trehalase
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