Tandem Mass Tag Approach Utilizing Pervanadate BOOST Channels Delivers Deeper Quantitative Characterization of the Tyrosine Phosphoproteome期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Tandem Mass Tag Approach Utilizing Pervanadate BOOST Channels Delivers Deeper Quantitative Characterization of the Tyrosine Phosphoproteome

Institution:	3. Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island;4. Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island;5. Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas

Abstract:	Download : Download high-res image (212KB) Download : Download full-size image Highlights •Detection of low-abundance phosphotyrosine-containing peptides is challenging. •Multiplexed TMT allows inclusion of modification(pTyr)-saturated boost channels. •Boost channels facilitate selection of pTyr precursor ions for fragmentation. •Quantitation depth is increased while maintaining accuracy and precision.

Keywords:	Tandem mass spectrometry phosphoproteome phosphorylation label-free quantification omics BOOST channel pervanadate phosphotyrosine proteomics superbinder tandem mass tag
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