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Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis
Affiliation:1. Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium;2. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, China;3. Department of Biomedicine, Aarhus University, Aarhus 8000, Denmark;4. Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China;5. Translational Cancer Research Unit, GZA Hospitals Sint-Augustinus, Antwerp 2610, Belgium;6. Center for Oncological Research, University of Antwerp, Antwerp 2000, Belgium;7. Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Aging, KU Leuven, Leuven 3000, Belgium;8. Laboratory for Precision Cancer Medicine, Translational Cell & Tissue Research, Department of Imaging & Pathology, KU Leuven, Leuven 3000, Belgium;9. Department of Immunology and Blood Transfusion, Leiden University Medical Center, Leiden 2300 RC, the Netherlands;10. OXURION NV, Leuven 3001, Belgium;11. BGI-Shenzhen, Shenzhen 518083, China;12. China National GeneBank, BGI-Shenzhen, Shenzhen 518120, China;13. Laboratory for Functional Epigenetics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium
Abstract:
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  • Keywords:endothelial cells  angiogenesis  choroidal neovascularization  tumor angiogenesis  scRNA-seq  metabolism
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