The Correlation Between Metabolic Disorders And Tpoab/Tgab: A Cross-Sectional Population-Based Study |
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| Institution: | 1. From the Department of Endocrinology and Metabolism and the institute of Endocrinology, The First Hospital of China Medical University, Shenyang, Liaoning, P.R. China;2. Department of Endocrinology, the First Hospital of Lanzhou University, Lanzhou, Gansu, P.R. China;3. Department of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China;4. Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, Jilin, P.R. China;5. Department of Endocrinology, Shanghai University of Medicine & Health Science Affiliated Zhoupu Hospital, Shanghai, P.R. China;6. Department of Endocrinology, The First Hospital of An Hui Medical University, Hefei, Anhui, P.R. China;7. Department of Endocrinology, Chinese PLA General Hospital, Beijing, P.R. China;8. Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing, P.R. China;9. Department of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, P.R. China;10. Department of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital of Ningxia Medical University, Yinchuan, Ningxia, P.R. China;11. Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, P.R. China;12. Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, P.R. China;13. Department of Endocrinology, Hohhot First Hospital, Hohhot, Inner Mongolia, P.R. China;14. Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China;15. Research center of Endocrine and Metabolic Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, P.R. China;16. Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China;17. Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, P.R. China;18. Department of Endocrine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, P.R. China;19. Department of Endocrinology, Hainan General Hospital, Haikou, Hainan, P.R. China;20. Department of Endocrinology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shanxi, P.R. China;21. Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China;22. Department of Endocrinology, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, P.R. China;23. Department of Endocrinology and Metabolism, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P.R. China;24. Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, P.R. China;25. Department of Endocrinology and Metabolism, People’s Hospital of Tibet Autonomous Region, Lhasa, Tibet, P.R. China;26. Department of Endocrinology, Qinghai Provincial People’s Hospital, Xining, Qinghai, P.R. China;27. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, P.R. China;28. Department of Endocrinology and Metabolism, Affiliated Hospital of Guiyang Medical University, Guiyang, Guizhou, P.R. China;29. Department of Endocrinology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China;30. Department of Endocrinology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, P.R. China;31. Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, P.R. China.;1. From the Barrow Pituitary Center, Barrow Neurological Institute and St. Joseph’s Hospital and Medical Center, University of Arizona College of Medicine and Creighton School of Medicine, Phoenix, Arizona;2. Department of Neurosurgery, University of California San Francisco, California Center for Pituitary Disorders, San Francisco, California;3. Division of Endocrinology and Molecular Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.;1. From the Department of Diabetes & Endocrinology, Assistant Professor of Medicine, Michigan State University College of Human Medicine, Grand Rapids, Michigan;2. Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Associate Professor of Medicine, Mayo Clinic, Rochester, Minnesota;3. Department of Nutrition Sciences, Associate Professor of Medicine, UAB Diabetes Research Center, University of Alabama at Birmingham, Birmingham, Alabama.;1. Department of Endocrinology, La Conception Hospital, 147 Boulevard Baille, 13005 Marseille, France.;1. From the Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People’s Republic of China;2. the Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, People’s Republic of China. |
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| Abstract: | Objective: Studies have shown that metabolic abnormalities influence the immune system. Because the prevalence of metabolic and autoimmune thyroid diseases has increased synchronously, the correlation between them was worth exploring. The study objective was to investigate the relationship between metabolic disorders and thyroid auto-antibodies in euthyroid subjects.Methods: Data were obtained from the Thyroid Diseases and Diabetes Mellitus project survey of 55,891 subjects from 31 provinces in China. The body mass index (BMI), waist circumference (WC), blood pressure, thyroid peroxidase antibodies (TPOAbs), thyroglobulin antibodies (TgAbs), thyroid-stimulating hormone (TSH), urinary iodine concentration, blood glucose, lipid profile, and uric acid levels were evaluated. Free thyroxine and free triiodothyronine levels were measured in patients with abnormal serum TSH levels.Results: In males, the BMI, WC, systolic blood pressure (SBP), diastolic blood pressure (DBP), and 2-hour post-glucose oral glucose tolerance test results of the TPOAb-/TgAb-positive group were significantly higher than those of the TPOAb-/TgAb-negative group. In females, the BMI, WC, SBP, DBP, total cholesterol, and low-density-lipoprotein cholesterol (LDL-C) in the TPOAb-/TgAb-positive group were significantly increased compared to the TPOAb-/TgAb-negative group. Multivariate analysis showed that in males, the odds ratio (OR) of positive TgAbs in the abdominal obesity group was 1.175 (95% confidence interval CI], 1.016 to 1.359; P = .03), and the OR of positive TPOAbs in the hyperuricemia group was 1.195 (95% CI, 1.041 to 1.372; P = .011). In females, the OR of positive TgAbs was 1.19 (95% CI, 1.068 to 1.326; P = .002) in the high LDL-C group.Conclusion: Obesity, high LDL-C, and hyperuricemia were positively correlated with the prevalence of positive thyroid autoantibodies in euthyroid subjects in a gender-dependent manner. This cross-sectional survey showed that metabolic disorders are associated with increased positive thyroid autoantibody levels in euthyroid subjects in a gender-dependent manner.Abbreviations: AIT = autoimmune thyroiditis; BMI = body mass index; CI = confidence interval; DBP = diastolic blood pressure; FPG = fasting plasma glucose; FT3 = free triiodothyronine; FT4 = free thyroxine; HbA1c = glycated hemoglobin; HDL-C = high-density-lipoprotein cholesterol; LDL-C = low-density-lipoprotein cholesterol; OGTT2hPG = oral glucose tolerance test 2-hours post-glucose; OR = odds ratio; SBP = systolic blood pressure; TC = total cholesterol; TG = triglycerides; TgAb = thyroglobulin antibody; TPOAb = thyroid peroxidase antibody; TSH = thyroid-stimulating hormone; UA = uric acid; WC = waist circumference |
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