Flow-induced Reorganization of Laminin-integrin Networks Within the Endothelial Basement Membrane Uncovered by Proteomics期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Flow-induced Reorganization of Laminin-integrin Networks Within the Endothelial Basement Membrane Uncovered by Proteomics

Institution:	1. Department of Molecular and Cellular Hemostasis, Sanquin Research, Amsterdam, The Netherlands;2. Department of Biomolecular Mass Spectrometry, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, The Netherlands

Abstract:	Download : Download high-res image (247KB) Download : Download full-size image Highlights ?Proteomics uncovers the flow-induced remodeling of the endothelial basement membrane. ?Flow alters the composition and localization of the laminin-integrin network. ?Flow induces proteolytic processing of LAMA4, resulting in shedding of LG4–5 region. ?TNFα- and flow-exposure induce a distinct proteomic signature with limited interplay.

Keywords:	Extracellular matrix inflammation label-free quantification mass spectrometry SILAC basement membrane endothelium flow integrin laminin
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