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Profiling Cell Signaling Networks at Single-cell Resolution

Affiliation:	3. Institute of Molecular Life Sciences, University of Zürich, 8057 Zürich, Switzerland;4. Molecular Life Sciences PhD Program, Life Science Zürich Graduate School, ETH Zürich and University of Zürich, 8057 Zürich, Switzerland

Abstract:	Download : Download high-res image (204KB) Download : Download full-size image Highlights •Signaling networks can be highly heterogeneous across cells in a tissue. •Various technologies allow analyzing signaling networks at single-cell resolution. •The advantages and limitations of each single-cell approach are summarized. •Confounding factors in single-cell signaling network analysis are discussed.

Keywords:	Signaling circuits phosphoproteome systems biology assay development pathway analysis single-cell analysis
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