Novel Proteome Extraction Method Illustrates a Conserved Immunological Signature of MSI-H Colorectal Tumors期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Novel Proteome Extraction Method Illustrates a Conserved Immunological Signature of MSI-H Colorectal Tumors

Authors:	Elez D. Vainer Juliane Kania-Almog Ghadeer Zatara Yishai Levin Gilad W. Vainer

Affiliation:	1. Department of Gastroenterology, Hadassah—Hebrew University Medical Center, Jerusalem, Israel;2. Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel;3. Department of Pathology, Hadassah—Hebrew University Medical Center, Jerusalem, Israel;4. De Botton Institute for Protein Profiling, The Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel

Abstract:	Download : Download high-res image (249KB) Download : Download full-size image Highlights •TOP: robust, bio-friendly FFPE proteome extraction method with less fixation bias. •Proteome of MSI-H colorectal cancer identifies immunobiology key elements. •MSI-H tumor displays an “INFg-STAT1 centric signature”. •Long-term IFNg induction In-vitro mimicks MSI-H signature.

Keywords:	Clinical proteomics colorectal cancer immunohistochemistry immunology molecular biology label-free quantification inflammatory response
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