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Serum Protein Profiling Reveals a Landscape of Inflammation and Immune Signaling in Early-stage COVID-19 Infection
Affiliation:1. Department of Clinical Laboratory & Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China;2. State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences-Beijing (PHOENIX Center), Beijing Institute of Lifeomics, Beijing, China
Abstract:
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  • Highlights
    • •In-depth profiling of the serum proteome in early-stage COVID-19 patients.
    • •A landscape of inflammation and immune signaling related to the SARS-CoV-2 infection.
    • •CCL2 and CXCL10 medicated cytokine signaling pathways may correlate with neutrophil and lymphocyte respectively.
    Keywords:Infectious disease  array analysis  protein array  antibodies  clinical proteomics  serum/plasma
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