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Global Proteome and Phosphoproteome Characterization of Sepsis-induced Kidney Injury

Authors:	Yi-Han Lin Maryann P Platt Haiyan Fu Yuan Gui Yanlin Wang Norberto Gonzalez-Juarbe Dong Zhou Yanbao Yu

Institution:	1. Infectious Diseases and Genomic Medicine Group, J. Craig Venter Institute, Rockville, Maryland;2. Division of Nephrology, Department of Medicine, University of Connecticut School of medicine, Farmington, Connecticut;3. Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

Abstract:	Download : Download high-res image (197KB) Download : Download full-size image Highlights ?Cecal Ligation Puncture (CLP) mouse model to study sepsis-induced kidney disease. ?Quantitative global proteome and phosphoproteome profiling of mouse kidneys. ?Highly significant candidate markers for onset and progression of AKI to CKD. ?Mechanistic insights into sepsis-associated kidney injuries.

Keywords:	Quantification phosphoproteome kidney disease infectious disease systems biology biomarker: diagnostic mass spectrometry omics acute kidney infection chronic kidney disease label-free quantitation
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