Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses

Institution:	3. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California;4. Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California;5. Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California;6. Department of Pharmacology and Experimental Therapeutics, Department of Neurology, Alzheimer''s Disease Research Center, Boston University, School of Medicine, Boston, Massachusetts

Abstract:	Download : Download high-res image (170KB) Download : Download full-size image Highlights •Mutant Tau dysregulates exosome cargo generated by human iPSC neurons. •Expression of P301L and V337M mutations of Tau in human iPSC neurons result in recruitment of distinct proteins to exosomes, and absence of control proteins to exosomes. •Tau mutations of FTDP-17 result in up- and downregulation of exosome proteins. •Altered proteome cargo of mTau exosomes may be involved in Tau pathogenesis in vivo in brain.

Keywords:	Exosomes protein identification neurodegenerative diseases signaling molecules alzheimer's disease neurobiology networks biogenesis dysregulation human iPSC neurons mutant tau
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