Glucose Metabolism in Healthy Subjects and in Patients with Carbohydrate and Lipid Metabolic Disorders |
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| Authors: | E. I. Sokolov A. L. Davydov N. T. Starkova A. M. Zyakun E. I. Maevskii E. V. Grishina |
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| Affiliation: | (1) Moscow State Medical and Stomatological University, ul. Delegatskaya 20/1, Moscow, 103473, Russia;(2) Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, pr. Nauki 5, Pushchino, Moscow oblast, 142292, Russia;(3) Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, pr. Nauki, Pushchino, Moscow oblast, 142292, Russia |
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| Abstract: | The rate of glucose oxidation was studied by measurement of the 13C concentration in expired air with simultaneous detection of the activity of the pyruvate dehydrogenase complex in subjects with obesity and patients with type II diabetes. Intake of small amounts of glucose did not change the rate of glucose oxidation in subjects with obesity as compared to healthy controls. However, intake of large amounts of glucose resulted in a considerable increase in the rate of glucose oxidation without a hypoxic shift. In patients with diabetes mellitus, the rate of glucose oxidation decreased with increasing tissue hypoxia. |
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