| 神经节苷脂类抑制BT325细胞系的生长 |
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| 引用本文： | 李爱华,黄如彬,杨典洱,金有豫. 神经节苷脂类抑制BT325细胞系的生长[J]. 生物化学与生物物理进展, 1997, 24(3): 242-245 |
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| 作者姓名： | 李爱华 黄如彬 杨典洱 金有豫 |
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| 作者单位： | 首都医科大学生物化学教研室，北京 100054;首都医科大学生物化学教研室，北京 100054;首都医科大学生物化学教研室，北京 100054;首都医科大学药物研究所，北京 100054 |
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| 摘 要： | 应用自提的神经节苷脂GM3, 牛脑神经节苷脂(bovine brain gangliosides, BBG)加入低血清培养的人多形成胶质细胞瘤BT325细胞中观察其对该细胞系的影响; 以及GM3、BBG对表皮生长因子(EGF)刺激该细胞系生长的拮抗作用. 结果表明GM3、BBG均能抑制BT325细胞生长，GM3的抑制作用远高于BBG, 其抑制率为60.28% (P＜0.01), BBG为19.33％，在含不同浓度的EGF培养液中分别加入GM3、BBG均可拮抗EGF对BT325生长的刺激作用, GM3的拮抗作用远高于BBG.
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| 关 键 词： | 神经节苷脂GM3，牛脑神经节苷脂，抑制作用，人多形成胶质细胞瘤BT325，表皮生长因子 |
| 收稿时间： | 1995-05-07 |
| 修稿时间： | 1996-11-11 |
Gangliosides Inhibit Growth of Human Glioblastma Multiform Cell Line BT325 |
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| LI Aihu,HUANG Rubin,YANG Dianer and JIN Youyu. Gangliosides Inhibit Growth of Human Glioblastma Multiform Cell Line BT325[J]. Progress In Biochemistry and Biophysics, 1997, 24(3): 242-245 |
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| Authors: | LI Aihu HUANG Rubin YANG Dianer JIN Youyu |
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| Affiliation: | Department of Biochemistry, Capital University of Medical Science, Bejing 100054, China;Department of Biochemistry, Capital University of Medical Science, Bejing 100054, China;Department of Biochemistry, Capital University of Medical Science, Bejing 100054, China;Institute of Pharmaceutics, Capital University of Medical Science, Beijing 100054, China |
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| Abstract: | Ganglioside GM3 and bovine brain Gangliosides(BBG) were added exogenously to human glioblastma multiform cell line BT325 to observe their effects on BT325. The results showed that GM3 and BBG inhibited BT325 cell growth. The maximum of cell proliferation inhibition rate of GM3 and BBG were 60.28% and 19.33%, respectively. GM3 and BBG were added to medium which has different concentration of EGF. Both GM3 and BBG inhibited the EGF-stimulated BT325 cell growth and the effects of GM3 is far stronger than BBG. |
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| Keywords: | ganglioside GM3 bovine brain gangliosides inhibition human glioblastoma multiform cell line BT325 epidermal growth factor (EGF) |
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