| 氨酰-tRNA合成酶对tRNA的识别 |
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| 引用本文： | 李勇,李彤,王恩多. 氨酰-tRNA合成酶对tRNA的识别[J]. 生物化学与生物物理进展, 1997, 24(1): 2-7 |
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| 作者姓名： | 李勇 李彤 王恩多 |
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| 作者单位： | 中国科学院上海生物化学研究所，分子生物学国家重点实验室, 上海 200031;中国科学院上海生物化学研究所，分子生物学国家重点实验室, 上海 200031;中国科学院上海生物化学研究所，分子生物学国家重点实验室, 上海 200031 |
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| 基金项目： | 国家自然科学基金重点资助项目. |
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| 摘 要： | 氨酰-tRNA合成酶(aaRS)与tRNA的相互作用保证了蛋白质生物合成的忠实性. 氨酰-tRNA合成酶对tRNA识别的专一性依赖于aaRS特定的催化结构域和tRNA分子特异的三级结构构象. 反密码子和接受茎(包括73位)在大多数aaRS对tRNA分子的识别过程中起着关键作用, 其他部位如可变口袋、可变(茎)环等, 甚至修饰核苷酸对于一些识别过程也有重要作用.
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| 关 键 词： | 氨酰-tRNA合成酶，tRNA，识别 |
| 收稿时间： | 1996-01-31 |
| 修稿时间： | 1996-04-18 |
Recognition of tRNAs by Aminoacyl-tRNA Synthetases |
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| LI Yong,LI Tong and WANG Enduo. Recognition of tRNAs by Aminoacyl-tRNA Synthetases[J]. Progress In Biochemistry and Biophysics, 1997, 24(1): 2-7 |
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| Authors: | LI Yong LI Tong WANG Enduo |
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| Affiliation: | State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry, Academia Sinica, Shanghai 200031, China;State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry, Academia Sinica, Shanghai 200031, China;State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry, Academia Sinica, Shanghai 200031, China |
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| Abstract: | The interaction between aminoacyl-tRNA synthetases(aaRS) and tRNAs maintains the fidelity of protein biosynhesis. The specificity of recognition of tRNAs by aminoacyl-tRNA synthetases(aaRS) depends on the definite catalytical domain of aaRS and the distinctive tertiary structural comformation of tRNAs. Anticodon and acceptor stem (including position 73) play key roles in most recognition of tRNAs by aminoacyl-tRNA synthetases, other positions such as variable pocket,variable (stem) loop, even modified nucleotides are also important in some recognition. |
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| Keywords: | aminoacyl-tRNA synthetases tRNAs recognition |
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