Bisorbicillinol inhibits Lyn tyrosine kinase for allergic response on RBL-2H3 cells |
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| Authors: | Kouichi Sugaya Takehito Terajima Aika Takahashi Jun-ichi Onose Naoki Abe |
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| Institution: | Department of Nutritional Science and Food Safety, Faculty of Applied Bio-Science, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan |
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| Abstract: | Bisorbicillinol, which is isolated from Trichoderma sp. USF2690, is an inhibitor of β-hexosaminidase release and tumor necrosis factor (TNF)-α, and Interleukin (IL)-4 secretion from rat basophilic leukemia (RBL-2H3) cells, with IC50 values of 2.8?μM, 2.9?μM and 2.8?μM respectively. We showed that the inhibitory mechanism of β-hexosaminidase release and TNF-α secretion involved inhibition of Lyn, a tyrosine kinase. The inhibitory activities of bisorbicillinol indicate that this compound is a new candidate anti-allergic agent. |
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| Keywords: | Bisorbicillinol Lyn β-Hexosaminidase TNF-α RBL-2H3 cells |
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