Determination of barbiturates and some neutral drugs in serum using quartz glass capillary gas chromatography |
| |
Authors: | Bengt Kinberger, Anders Holm n,Peter Wahrgren |
| |
Affiliation: | Department of Clinical Chemistry, Central Hospital, 301 85 Halmstad Sweden |
| |
Abstract: | Rapid methods for the glass capillary gas chromatographic determination of barbiturates and some neutral drugs are described. The analysis of barbiturates was performed using a nitrogen—phosphorus selective detector (NPD). The barbiturates were recovered from serum using charcoal adsorption followed by extraction with methylene chloride. The drugs were then alkylated by means of the Claisen carbonate method. Neutral drugs were extracted simultaneously with the barbiturates. The neutral drugs were determined underivatized with a flame ionization detector. In the underivatized form the barbiturates were not stable on the quartz column used. The selectivity of derivatization combined with an NPD was used to determine the barbiturates in the presence of neutral drugs with the aid of retention data. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |