Assessment of caspase 3 activity in rabbit myocardial tissue during experimental hemodynamic overload of the left ventricle of the heart |
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| Authors: | M L Blagonravov M V Onufriev E A Demurov N V Gulyaeva V A Frolov |
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| Institution: | (1) Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, ON, Canada;(2) Eastern Ontario Regional Forensic Pathology Unit, The Ottawa Hospital, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada; |
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| Abstract: | It is well known that chronic overload of the cardiac left ventricle is accompanied by an increase in the cardiomyocyte apoptosis
rate. However, direction and extent of changes in programmed cell death under an acute overload of the left ventricle still
requires detailed investigation (as its pathogenesis significantly differs from chronic overload). Caspase-3 activity has
been investigated in left ventricle myocardium of rabbits on days 1, 3, and 5 after modeling of left ventricle hemodynamic
overload caused by experimental stenosis of the ascending aorta. Control group included intact animals. It was found that
caspase-3 activity significantly increased in both ventricles on day 1; it increased more than twofold above control values
on day 3 and decreased up to nearly control values on day 5. Based on these data it was concluded that the acute hemodynamic
overload of the left ventricle may be a cause of increased apoptosis in the myocardial tissue of both cardiac ventricles during
first days of the pathological process. |
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