Preparation and evaluation of 99mTc-t-butylisonitrile (99mTc-TBI) for myocardial imaging: a kit for hospital radiopharmacy |
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| Affiliation: | 1. Isopharm, Radiopharmaceuticals Operations, Board of Radiation and Isotope Technology, BARC Vashi Complex, Vashi, New Bombay 400 705, India;2. Radiation Medicine Center, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Parel, Bombay 400 012, India;1. Department of Physics, Sacred Heart College (Autonomous), Tirupattur 635601, Tamil Nadu, India;2. Department of Physics, Loyola College, Chennai 600 034, Tamil Nadu, India;1. Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt;2. Department of Analysis and Evaluation, Egyptian Petroleum Research Institute, Cairo 11727, Egypt;3. Chemistry Department, Faculty of Women for Arts, Science, and Education, Ain Shams University, Cairo 11757, Egypt;1. Department of Chemistry, Presidency University, Kolkata, 700073, India;2. Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, 208016, India |
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| Abstract: | A previous method was modified to obtain [99mTc(TBI)6]+ by reacting Zn(TBI)2Br2 directly with 99mTcO−4 in the presence of Sn2+ ions. [Cu(TBI)4]Cl was next used as a source of TBI. On reaction with 99mTcO−4 and Sn2+ ions for 3 min at 100 °C, [99mTc(TBI)6]+ product of radiochemical purity >90% and yield >70% was obtained. Data of biodistribution in rats (2–2.5% in heart) and biokinetics in rabbits were satisfactory. The kit formulation was found to be stable and also safe for administration. |
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