The synthesis of [14C]SCH 40054/A-57219 hydrochloride |
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| Institution: | 1. Faculty of Polymer Engineering, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran;2. Institute of Polymeric Materials, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran |
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| Abstract: | A two-step, no-carrier-added synthesis of 2-(4-amino-3,5-dichlorobenzyl)14C)imidazoline, SCH 40054/A-57219 (1) was performed starting with 14C]KCN. The labelled cyanide ion was reacted with the appropriate benzyl chloride to give a nitrile. The nitrile was converted to an imidazoline by reaction with ethylene diamine. Purification of the product was complicated by its instability at neutral or alkaline pH. |
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