Synthesis and biological activity of the intercalating agent 3-Acetamido-5-[123125I]iodo-6-aminoacridine |
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| Affiliation: | 2. Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD;1. Department of Chemistry, St. Francis College for Women, Hyderabad 500016, India;2. Department of Chemistry, GITAM School of Science, GITAM Deemed to be University Hyderabad Campus, 502329, India;3. Department of H&S (Chemistry), Gokaraju Rangaraju Institute of Engineering and Technology, Hyderabad 500090, India;4. Department of Chemistry, B V Raju Institute of Technology (BVRIT), Narsapur 502313, India;5. Chemistry Division, BS&H Department, BVRIT College of Engineering for Women, Hyderabad 500090, India |
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| Abstract: | 3-Acetamido-5-iodo-6-aminoacridine (3), a derivative of the known intercalating agent proflavine (3,6-diaminoacridine) (1) was synthesized, and no-carrier-added 123I and 125I labeled compounds prepared. Compound 3 was taken up by live cells and localized in the nucleus. The intracellular concentration of [125I]3 was 7-fold greater in human prostate carcinoma (PC-3) cells than in normal Chinese hamster lung fibroblast (V-79) cells. |
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