Local sensitivity to excitatory and inhibitory amino acids in spinal interneurons of the lamprey |
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Affiliation: | 1. Biocenter Cologne, Department of Animal Physiology, Zoological Institute, Zülpicher Strasse 47b, Cologne 50674, Germany;2. The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, Solnavägen 9, Stockholm 171 65, Sweden;3. Institute for Genetics, University of Cologne, Zülpicher Straße 47a, Cologne 50674, Germany |
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Abstract: | Sensitivity to glutamate, aspartate, glycine and GABA was examined in giant interneurons of the lamprey spinal cord.1. The membrane potentials evoked by iontophoretic application decayed with varied time constants specific to amino acids: 2.5 sec for glutamate, 6.3 sec for glycine and 10.3 sec for GABA. li|2. Bath-applied amino acids reduced the input resistance by varying degrees; when glutamate effect was taken as 1, relative effects of aspartate, glycine and GABA were 0.28, 40.5 and 12.3, respectively.3. Glutamate sensitivity was fairly uniform in both the soma and the dendrites. Glycine sensitivity, as well as GABA, was high in the soma and declined steeply along the dendrites by iontophoresis. |
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