The actions of the catch relaxing peptide,carp, on identified Helix central neurons |
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| Institution: | 1. College of Life Science, Henan Normal University, Xinxiang, Henan 453007, China;2. Henan International Joint Laboratory of Aquatic Toxicology and Health Protection, Henan Normal University, Xinxiang, Henan 453007, China;3. Department of Food Toxicology and Contaminants, National Research Centre, Dokki, Cairo 12622, Egypt;1. College of Life Science, Henan Normal University, Xinxiang, Henan 453007, China;2. Henan International Joint Laboratory of Aquatic Toxicology and Health Protection, Henan Normal University, Xinxiang, Henan 453007, China;3. Department of Food Toxicology and Contaminants, National Research Centre, Dokki, Cairo 12622, Egypt |
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| Abstract: | 1. The action of the catch relaxing peptide CARP (H-Ala-Met-Pro-Met-Leu-Arg-Leu-amide, AMPMLRL-amide) has been studied on Helix central neurons.2. CARP, at thresholds of 1 nM or less, excited some cells while inhibiting others. CARP modulated the action of acetylcholine, e.g. at 10–100 nM CARP, the acetylcholine response was greatly reduced.3. The inhibitory action of CARP is mediated through an increase in chloride permeability while CARP excitation was dependent on sodium and calcium.4. The use of blocking agents suggested that CARP and acetylcholine acted on separate receptors. |
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