A comparison of 131I-labeled antibodies, 2-deoxy-2-[18F]fluoro-d-glucose and 68Ga-EDTA in the imaging of human tumor xenografts in nude mice |
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| Affiliation: | 1. University Central Hospital of Helsinki, Meilahti Hospital, Laboratory Department, SF-00290 Helsinki, Finland;2. University of Helsinki, Department of Radiochemistry, Unioninkatu 35, SF-00170 Helsinki, Finland;3. University of Helsinki, Department of Bacteriology and Immunology, Haartmaninkatu 3, SF-00290 Helsinki, Finland;1. Nuclear Medicine Department, University Hospital “Marqués de Valdecilla”, Cantabria University, Molecular Imaging Group IDIVAL, Santander, Spain;2. Radiology Department, University Hospital “Marqués de Valdecilla”, Cantabria University, Santander, Spain;3. Internal Medicine Department, University Hospital “Marqués de Valdecilla”, Cantabria University, Santander, Spain;1. Department of Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310000, China;2. Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310000, China;3. Department of Surgery, First Affiliated Hospital, Zhengzhou University School of Medicine, Zhengzhou, Henan 420052, China;4. Department of Radiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;5. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA;1. Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan;2. Biomedical Imaging Research Center, University of Fukui, Fukui, Japan;1. Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea;2. Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea;3. Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea;4. Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea;5. Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea;6. Center for Nanomolecular Imaging and Innovative Drug Development, Advanced Institutes of Convergence Technology, Suwon, Gyeonggi-do, Republic of Korea |
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| Abstract: | Three different biological properties—glucose metabolism, gallium imaging and antigen-antibody interaction—have been targeted to image human tumor xenografts implanted in nude mice. Seventy-two experiments were performed in 25 nude mice. Two types of human tumors were used: colorectal carcinoma SW 1116 and melanoma WM 9. Immunoscintigraphic studies produced the highest tumor sampling and confirmed earlier findings that F(ab′)2 fragments generate better tumor images than whole antibodies. |
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