Continuous production of acetic acid using immobilized acetobacter aceti in a three-phase fluidized bed bioreactor |
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Institution: | 1. Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Lehrstuhl für Strömungsmechanik, Cauerstraße 4, 91058 Erlangen, Germany;1. Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA;2. Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA |
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Abstract: | Continuous operation of a three-phase fluidized bed bioreactor using immobilized cells showed that both immobilized and suspended cells contributed to the production of acetic acid. Unlike the rapid decrease in the productivity at dilution rates above 0.25 h?1 in the free cell fermentation, the productivity was little affected by the dilution rate in the immobilized cell fermentation. Theoretical models were proposed for the continuous process. The models approximately agreed with the experimental results. Experimental results and/or theoretical calculations based on the kinetic models showed that suspended cells were important in the production of acetic acid if the solid holdup was small or if gel radius was large. Theoretical calculations showed that an optimal solid holdup or gel size existed at higher dilution rates because of the kLa dependence on solid holdup and particle diameter. |
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