Recurrent pregnancy loss in a subject with heterozygote factor V Leiden mutation; a case report |
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| Authors: | Reza Ebrahimzadeh-Vesal Roza Azam Arvin Ghazarian Mogge Hajesmaeili Najmeh Ranji Mohammad Reza Ezzati Mehrdad Sadri Mohammad Ali Mohammadi Siamak Khavandi |
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| Affiliation: | 1.Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.;2.Department of Biology, Islamic Azad University of Parand, Tehran, Iran.;3.Department of Genetics, Faculty of Sciences, Islamic Azad University, Rasht Branch, Rasht, Iran.;4.Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. |
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| Abstract: | Recurrent pregnancy loss is usually defined as the loss of two or more consecutive pregnancies before 20 weeks of gestation, which occurs in approximately 5% of reproductive-aged women. It has been suggested that women with thrombophilia have an increased risk of pregnancy loss and other adverse pregnancy outcomes. Thrombophilia is an important predisposition to blood clot formation and is considered as a significant risk factor for recurrent pregnancy loss. The inherited predisposition to thrombophilia is most often associated with factor V Leiden mutation, prothrombin G20210A mutation, and methylenetetrahydrofolate reductase C677T and A1298C gene variants. The net effect is an increased cleavage of prothrombin to thrombin and excessive blood coagulation. Key Words: Recurrent pregnancy loss, Hereditary thrombophilia, Factor V Leiden mutation |
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