| RNA干涉技术 |
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| 引用本文： | 胡迎春,李刚,吴德昌. RNA干涉技术[J]. 生物技术通讯, 2004, 15(3): 285-288 |
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| 作者姓名： | 胡迎春 李刚 吴德昌 |
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| 作者单位： | 军事医学科学院,放射医学研究所,北京,100850 |
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| 摘 要： | RNA干涉(RNAi)技术是利用一些小的双链RNA来高效、特异地阻断体内特定基因的表达，并促使mRNA降解，从而诱使细胞表现出特定基因缺失的表型。本从RNAi技术的历史、作用机制、研究策略、研究现状及应用前景等几个方面进行了综述，预测RNAi将会给基因治疗的发展带来新的希望。
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| 关 键 词： | RNA干涉 RNAi 基因 表达 双链RNA 基因沉默 |
| 文章编号： | 1009-0002(2004)03-0285-04 |
| 修稿时间： | 2003-11-12 |
RNA interference |
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| HU Ying-chun,LI Gang,WU De-chang Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing,China. RNA interference[J]. Letters in Biotechnology, 2004, 15(3): 285-288 |
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| Authors: | HU Ying-chun LI Gang WU De-chang Institute of Radiation Medicine Academy of Military Medical Sciences Beijing China |
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| Affiliation: | HU Ying-chun,LI Gang,WU De-chang Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing100850,China |
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| Abstract: | Small interfering RNAs(siRNAs)are short,double-stranded RNA molecules that can target complementary mRNAs for degradation via a cellular process termed RNA interference(RNAi).In this paper,the history and mechanism of RNAi as well as the method and advance of RNAi research were summarized. |
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| Keywords: | RNA interference double-stranded RNA gene silencing |
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