Synthesis of human endothelin-1 precursors in Escherichia coli |
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| Authors: | T Watanabe Y Itoh K Ogi C Kimura N Suzuki H Onda |
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| Affiliation: | Tsukuba Research Laboratories, Takeda Chemical Industries, Ltd, Ibaraki, Japan. |
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| Abstract: | Endothelin, the most potent vasoconstrictor found in nature, is thought to be important in the regulation of blood pressure and/or local blood distribution. Human placenta cDNA fragment encoding preproendothelin-1 (preproET-1) and its carboxyl terminal mature precursor (C-matured precursor) was expressed in E. coli. These products were characterized by both enzyme immunoassay and Western blot analysis. |
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