Acute effects of testosterone on serum PGE2 levels in male dogs |
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| Authors: | Lester A Klein Jeffrey S Stoff Jonathan Ellis |
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| Institution: | 1. Charles A. Dana Research Institute and the Harvard-Thorndike Laboratory, USA;2. Departments of Surgery (Urology) and Medicine Beth Israel Hospital and Harvard Medical School Boston, Massachusetts, USA |
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| Abstract: | Serum prostaglandin levels are influenced by testosterone. To test the hypothesis that the effect of testosterone is mediated through the prostate gland, testosterone was given acutely to intact and to prostatectomized male dogs. Intact dogs responded to testosterone with an abrupt, transient rise in plasma PGE2 levels; prostatectomized dogs did not respond. We conclude that testosterone has an acute effect on the prostate gland which results in release of PGE2 into the blood stream. |
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