On the mechanism of action of 15-methyl-PGF2α as an abortifacient |
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Authors: | Krister Gren Kerstin Svanborg |
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Institution: | Department of Obstetrics and Gynecology, Karolinska Hospital, S-104 01 Stockholm and Department of Chemistry II S-104 01 Stockholm Sweden |
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Abstract: | Several hours following administration of long acting vaginal suppositories containing 3.0 mg of 15-methyl-PGF2α for interruption of second trimester pregnancies there is an up to 10-fold increase in endogenous production of PGE2 and PGF2α before abortion as reflected by gas chromatographic-mass spectrometric determination of the major plasma metabolites of PGE2 and PGF2α. The data suggest that this increased formation of endogenous prostaglandins contributes to the induced uterine activity during the latter part of the abortion process. |
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