Synthesis and antifungal activities of phenylenedithioureas |
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| Authors: | Phuong Truong Khac-Minh Thai Van Ha Nguyen Thi Ngoc Phuong Huynh Thi |
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| Affiliation: | Pharmaceutical Chemistry Department, Faculty of Pharmacy, HoChiMinh City Medicine and Pharmacy University, 41-43 DinhTienHoang Street, 1st District, HoChiMinh City, Viet Nam. phuongnq@hcm.ftp.vn |
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| Abstract: | A total of 20 new phenylenedithiourea derivatives was synthesized by reaction of phenylenediisothiocyanates with aromatic amines as aminobenzoic, aminosalicylic acid and their derivatives. Their chemical structures were confirmed by elemental analysis, IR spectrometry and 1H NMR. The compounds were screened for in vitro antifungal, antibacterial activities and some of them have strong antifungal activities comparable to the activity observed for ketoconazole. |
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