Effect of aging on prolactin regulation of rat striatal dopamine receptor concentrations |
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Authors: | P Levin M Haji J A Joseph G S Roth |
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Institution: | Gerontology Research Center, National Institute on Aging, NIH, Baltimore City Hospitals, Baltimore, MD 21224, USA |
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Abstract: | Administration of highly purified rat prolactin by miniosmotic pump increases striatal dopamine receptor concentrations in both mature (4-6 months) and senescent (24 months) male Wistar rats. Although receptor levels in untreated rats are about 30% lower in the senescent group, elevated levels following prolactin are not significantly different between ages. Increases in circulating prolactin levels after 7 days of treatment were not detectable at the low concentrations used (150 ng/hr). In fact, there was a trend toward decreases in circulating prolactin concentrations to the same level in both groups after treatment, despite substantially elevated basal levels in many of the senescent rats. |
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